- Supplementing creatine may benefit cognition as muscle and brain cells use creatine to access more energy when demand is high. They store creatine as phosphocreatine, which acts to regenerate the energy-providing adenosine triphosphate (ATP) [^1] # References [^1]: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-023-03146-5